Medicinal Innovation Source of Liliaceae: Mapping Phytochemical Diversity and Pharmacological Breakthroughs

Abstract: The Liliaceae family, encompassing a diverse range of flowering medicinal plants, is a rich source of bioactive alkaloids with significant pharmacological potential. These alkaloids possess potent therapeutic properties and have long been utilized in traditional ethnomedicinal practices. Their pharmacological activities span a wide spectrum, including anti-inflammatory, antimicrobial, anticancer, antidiabetic, and neuroprotective effects. In recent years, advancements in phytochemical and pharmacological research have facilitated the isolation and characterization of novel alkaloid compounds from key Liliaceae genera such as Fritillaria, Allium, and Lilium. These compounds have demonstrated promising results in preclinical studies through mechanisms such as antioxidant modulation, apoptosis induction, enzyme inhibition, and immune regulation. This review highlights the structural diversity of alkaloids derived from Liliaceae and explores recent progress in understanding their pharmacological relevance.