Psychedelics, Harm Reduction, and Life's Big Questions: Making Sense of Spirituality and Religion After the Journey

ABSTRACT The interplay between psychedelic use, mental health, and spiritual, religious, or ‘mystical’ experiences continues to be investigated through clinical research. While many studies focus on general mechanisms underlying these compounds, analysis of real‐life accounts from individuals is underrepresented. To fill that gap, this ethnographic study explores the question of how members of a psychedelic integration group in the Southeastern U.S. perceive the impact of psychedelics on their spiritual and religious outlook. Thematic analysis revealed that psychedelic encounters helped some to resolve religious conflicts, such as estrangement from religion or adverse religious associations, while nearly all reported a greater sense of spiritual connection. Noted challenges included perceived or actual religious condemnation of psychedelics, the absence of sought‐after experiences, and difficulties interpreting ineffable occurrences. Findings reinforce the need for attention to spirituality when addressing psychedelic use and mental health, arguing that doing so reduces harm and optimizes benefits.