A Promising Approach to Target Cancer for Anticancer Drug Delivery via Engineered Cubosomal Nanocarriers

Abstract: Carcinoma is a worldwide concern of well-being that leads health concern leading to mor-tality and disability. Although current treatment procedures offer some efficacy, they are not devoid of constraints and potential adverse reactions. Over the past few years, tremendous progress has emerged in newer strategies like immunotherapy and novel drug delivery systems, such as designing formula-tions utilising utilizing non-lamellar liquid-crystalline nanoparticles, known as lyotropic systems. Among them, cubosomes are one of the distinct categories of nanocarriers, formed by utilising utilizing precise proportions of amphiphilic lipids. Cubosomes are known for their ability to be compatible with living organisms and their flexibility in transporting drugs, allowing for the administration of pharma-ceuticals through many pathways. Several preclinical investigations have been reported to explore the future of cubosomes in cancer therapy and theranostic applications. The findings suggest that nano-technology and cancer therapies like immunotherapy have significant potential for tailored and effi-cient treatment approaches. Cubosomes can offer a promising contribution to the discipline of cancer research and the goal of enhancing therapeutic innovations. However, extensive research is required to confirm the safety, drug release mechanism, and stability of these nanocarriers. It covers a brief overview of cancer therapy including immunotherapy, advantages of targeted drug delivery, general aspects on of cubosomes, types of cubosomes, structural components, and preparation methods, fol-lowed by the mechanism of release, and discoveries on cubosomes as drug delivery for various cancers covering breast, colorectal, lung, liver, cervical, skin, etc. along with the future perspectives of other novel therapies like immunology in cancer.