Jiangtang Decoction for Type 2 Diabetes and NAFLD: Integrative Analysis via Network Pharmacology, Mendelian Randomization, Molecular Docking, and In Vitro Validation
This study identified eight genes that are genetically predicted to be causal for the therapeutic effects of JTD on both T2DM and NAFLD, thereby establishing a genetic link between the conditions. These targets and associated pathways illuminate common underlying mechanisms, supporting JTD's potential for integrated treatment strategies and providing a basis for further investigation.
Authors
- Siying Weng (ORCID: https://orcid.org/0000-0002-9110-1098)
- Wenbo Gong
- Xiaoyan Lu (ORCID: https://orcid.org/0000-0003-2242-0359)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Endocrine Metabolic & Immune Disorders - Drug Targets
- Published
- 2025-08-22
- DOI
- https://doi.org/10.2174/0118715303424915250818045151
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50