A Comparative Analysis of Grip Strength Evaluation Methods in a Large Cohort of Aged Mice
Combining multiple grip strength assessments improves measurement reliability in aging studies. The newly proposed SS2 and SS3 scores provide a streamlined yet robust alternative to SS5, improving standardization and facilitating future comparisons in preclinical sarcopenia research. Our findings also challenge the routine normalization of grip strength to body weight in geriatric mice, emphasizing the importance of using absolute values to avoid bias.
Authors
- Peter L.J. de Keizer (ORCID: https://orcid.org/0000-0002-6948-925X)
- Fiorenza Orlando (ORCID: https://orcid.org/0000-0001-7351-4430)
- Marco Malavolta (ORCID: https://orcid.org/0000-0002-8442-1763)
- Laura Gerosa (ORCID: https://orcid.org/0000-0003-0503-5328)
- Beatrice Bartozzi
- Esmée Bouma
- Giovanni Lai (ORCID: https://orcid.org/0009-0006-1444-6777)
- Maria Elisa Giuliani (ORCID: https://orcid.org/0000-0002-7487-5171)
- Diana A. Putavet (ORCID: https://orcid.org/0000-0002-8487-5802)
- G Lombardi (ORCID: https://orcid.org/0000-0002-5957-3132)
- Serena Marcozzi (ORCID: https://orcid.org/0000-0001-5873-5753)
- Giorgia Bigossi (ORCID: https://orcid.org/0000-0002-3445-4401)
- Amir Mohammad Malvandi (ORCID: https://orcid.org/0000-0003-1243-2372)
Institutions
- Marche Polytechnic University (IT)
- University Medical Center Utrecht (NL)
- Istituto Clinico Sant'Ambrogio (IT)
- Hycult Biotech (Netherlands) (NL)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1002/jcsm.70050
- Citations
- 3
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Ministero della Salute