Clinicopathological features of Chinese ovarian cancer patients with double heterozygosity for cancer-predisposed genes
Our study suggests that BRCA1 variant seems to drive the phenotypic expressions of ovarian cancer patients with DH. The management of these patients might be like BRCA1-mutated patients. Harboring DH may further increase the family member's chance of acquiring cancer of various types.
Authors
- Hongyan Guo (ORCID: https://orcid.org/0000-0001-6917-5341)
- Tongxia Wang
- Tong Gao (ORCID: https://orcid.org/0000-0002-7308-9988)
- Yi‐Ming Fan (ORCID: https://orcid.org/0000-0002-6206-1306)
- Yan Liu (ORCID: https://orcid.org/0000-0002-2816-7166)
- Yuan Li (ORCID: https://orcid.org/0000-0001-5651-819X)
- Wenyan Wang (ORCID: https://orcid.org/0000-0002-7486-8342)
- Qiyu Liu (ORCID: https://orcid.org/0000-0003-0924-4514)
- Yan Jin (ORCID: https://orcid.org/0009-0006-5357-0420)
- Manqi Wu (ORCID: https://orcid.org/0009-0004-0418-342X)
- Cuiyu Huang
Institutions
- Peking University (CN)
- Kunming Medical University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s12885-025-14835-0
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Peking University
- Peking University Third Hospital