Ursolic Acid Inhibits Triple-Negative Breast Cancer Progression by Modulating theFGFR1/AKT/ERK Pathway: Evidence from Network Pharmacology andExperimental Validation
Our findings demonstrate that UA inhibits the FGFR1/AKT/ERK pathway by directly targeting FGFR1, thereby suppressing TNBC progression and supporting its potential as a therapeutic agent for TNBC treatment.
Authors
- Pu Zhao (ORCID: https://orcid.org/0000-0001-6164-8300)
- Shuhui You (ORCID: https://orcid.org/0009-0003-5002-7391)
- Weiqiang Guo (ORCID: https://orcid.org/0000-0001-7899-8219)
- Ziming Chen (ORCID: https://orcid.org/0000-0001-5987-0148)
- Min Xiang (ORCID: https://orcid.org/0000-0001-9222-798X)
- Xiaoxiao Wang (ORCID: https://orcid.org/0000-0002-4458-9166)
- Xin Liu (ORCID: https://orcid.org/0000-0003-0813-5164)
- Yahan Gao (ORCID: https://orcid.org/0000-0003-1312-4339)
- Min Qian (ORCID: https://orcid.org/0000-0002-3410-1753)
Institutions
- Suzhou University of Science and Technology (CN)
- Suzhou Vocational Health College (CN)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-08-22
- DOI
- https://doi.org/10.2174/0118715206379579250722053647
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00