Machine learning identifies clinical sepsis phenotypes that translate to the plasma proteome
The identified clinical phenotypes reflected varying degrees of sepsis severity and were mirrored in the plasma proteome. Proteomic profiling offered novel insights into the molecular mechanisms underlying sepsis and enabled a deeper characterization of the identified phenotypes.
Authors
- Malte Bayer (ORCID: https://orcid.org/0000-0003-1060-8856)
- Thilo von Groote
- Thilo Bracht (ORCID: https://orcid.org/0000-0002-1194-6614)
- Ulrich Limper (ORCID: https://orcid.org/0000-0001-9927-4180)
- Stefan Ehrentraut (ORCID: https://orcid.org/0000-0001-5747-6737)
- Dietrich Henzler (ORCID: https://orcid.org/0000-0001-5511-6885)
- Matthias Unterberg (ORCID: https://orcid.org/0000-0002-1500-1984)
- Alexander Zarbock (ORCID: https://orcid.org/0000-0002-2124-1714)
- Tim Rahmel (ORCID: https://orcid.org/0000-0002-7039-6288)
- K Käppler
- Lars Palmowski
- Helge Haberl
- Katrin Marcus (ORCID: https://orcid.org/0000-0002-3313-8845)
- Björn Koos (ORCID: https://orcid.org/0000-0002-0544-4124)
- Katharina Rump (ORCID: https://orcid.org/0000-0003-2220-519X)
- Michael Adamzik (ORCID: https://orcid.org/0000-0002-7188-4873)
- Barbara Sitek
- Alexander Wolf (ORCID: https://orcid.org/0000-0001-8875-586X)
- Karin Schork (ORCID: https://orcid.org/0000-0003-3756-4347)
- Hartmuth Nowak (ORCID: https://orcid.org/0000-0002-6509-1463)
- Dominik Ziehe
- Martin Eisenacher (ORCID: https://orcid.org/0000-0003-2687-7444)
- Maike Weber (ORCID: https://orcid.org/0000-0002-7730-7436)
Institutions
- Witten/Herdecke University (DE)
- University Hospital Bonn (DE)
- University Hospitals of the Ruhr-University of Bochum (DE)
- University Hospital Münster (DE)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Herford Hospital (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Infection
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1007/s15010-025-02628-3
- Citations
- 6
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- Ruhr-Universität Bochum