The Discovery and Development of an Iridium‐Catalyzed N→C Alkyl Transfer Reaction
Under Ir-catalyzed conditions, N-2°-alkyl or N-3°-alkyl substituents of diverse tertiary aryl amides can be exchanged with the ortho-aryl C─H bond of the aromatic unit. These alkyl transfer processes employ a homochiral diphosphonite ligand, and this enforces notable levels of enantioconvergency for non-stereodefined 2°-alkyl substituents. Related processes allow the intermolecular transfer of N-2°-alkyl substituents, providing a convenient means of introducing difficult-to-install ortho-alkyl units.
Authors
- Lyman J. Feron
- John F. Bower (ORCID: https://orcid.org/0000-0002-7551-8221)
- L. Anders Hammarback (ORCID: https://orcid.org/0000-0003-1336-6848)
- Richard J. Mudd (ORCID: https://orcid.org/0000-0002-4988-7496)
- Phillippa Cooper (ORCID: https://orcid.org/0000-0002-8422-0945)
- Erin C. Boddie
Institutions
- AstraZeneca (United Kingdom) (GB)
- University of Liverpool (GB)
- University of Bristol (GB)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1002/anie.202509193
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- AstraZeneca
- European Research Council