High Expression of <i>NTRK1</i> in <i>ETV6::RUNX1</i> Positive Acute Lymphoblastic Leukaemia Drives Factor Independence and Sensitivity to Larotrectinib
NTRK1 overexpression has not previously been reported in B-ALL and was associated with increased relapse in patients with ETV6::RUNX1 and NTKR1 overexpression. The in vitro success of larotrectinib treatment warrants further in vivo investigation and may be a viable therapeutic addition for patients with ETV6::RUNX1 B-ALL and NTRK1 overexpression.
Authors
- Michael Osborn (ORCID: https://orcid.org/0000-0002-1288-9930)
- David T Yeung (ORCID: https://orcid.org/0000-0002-7558-9927)
- Rishi S. Kotecha (ORCID: https://orcid.org/0000-0003-1836-4075)
- Susan L. Heatley (ORCID: https://orcid.org/0000-0001-7497-6477)
- Luke Quinlan
- Michelle J. Henderson (ORCID: https://orcid.org/0000-0003-2741-3852)
- Jacqueline Rehn (ORCID: https://orcid.org/0000-0001-5043-6943)
- Deborah L. White (ORCID: https://orcid.org/0000-0003-4844-333X)
- Andrew S. Moore (ORCID: https://orcid.org/0000-0001-8062-1779)
- Barbara J. McClure (ORCID: https://orcid.org/0000-0002-5201-4127)
- Frank Alvaro (ORCID: https://orcid.org/0000-0003-2828-8758)
- Elyse C. Page (ORCID: https://orcid.org/0000-0002-8990-2574)
- Michelle Martin
Institutions
- Royal Adelaide Hospital (AU)
- The University of Queensland (AU)
- The Kids Research Institute Australia (AU)
- Curtin University (AU)
- Princess Margaret Hospital for Children (AU)
- Women's and Children's Hospital (AU)
- UNSW Sydney (AU)
- Children’s Health Queensland Hospital and Health Service (AU)
- Monash Children’s Hospital (AU)
- Children's Cancer Institute Australia (AU)
- ANZCHOG (AU)
- South Australian Health and Medical Research Institute (AU)
- John Hunter Children's Hospital (AU)
- Australasian Leukaemia and Lymphoma Group (AU)
- Perth Children's Hospital
- The University of Adelaide (AU)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1002/pbc.31983
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Health and Medical Research Council