Timosaponin B- II Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells via PI3K/AKT/GSK3β Signaling Pathway
TB-II stimulates the proliferation and osteogenic maturation of hPDLSCs in vitro by activation of the PI3K/AKT/GSK3β signaling axis. In vivo investigations using OTM model further demonstrate that TB-II enhances periodontal tissue regeneration. Collectively, these results highlight the therapeutic potential of TB-II in preventing relapses following OTM, positioning it as a viable candidate for clinical strategies aimed at stabilizing orthodontic outcomes.
Authors
- Zhaoyan Wu (ORCID: https://orcid.org/0000-0002-9589-1728)
- Xiaobin Cui
- Daiwei Yang (ORCID: https://orcid.org/0009-0001-7501-7347)
- Rui Dong (ORCID: https://orcid.org/0000-0001-9645-4768)
- Jun Zhang (ORCID: https://orcid.org/0000-0001-9761-2502)
- Yuxing Zhang (ORCID: https://orcid.org/0000-0003-4469-8837)
- Peng Yang (ORCID: https://orcid.org/0000-0002-4118-5959)
Institutions
- Shandong University (CN)
Publication Details
- Journal
- Stem Cell Reviews and Reports
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1007/s12015-025-10962-0
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00