Lineage switch of adult B-cell acute lymphoblastic leukaemia to acute myeloid leukaemia following B-cell-directed therapy
Lineage switch is a rare complication observed after B-cell targeted therapies; however, evidence remains limited.Specific genetic alterations, such as KMT2A abnormalities, may predispose leukemic clones to lineage plasticity.Close monitoring for immunophenotypic evolution is essential for timely recognition and clinical management of lineage switch.
Authors
- Charles Foucar (ORCID: https://orcid.org/0000-0001-7972-6979)
- Daniel Babu (ORCID: https://orcid.org/0000-0003-1968-0061)
- Ala Ebaid
- Darrell D. Horton (ORCID: https://orcid.org/0000-0002-6611-6773)
- Oscar Felipe Borja Montes (ORCID: https://orcid.org/0000-0003-3569-9360)
- Alejandro Toro-Pedroza (ORCID: https://orcid.org/0009-0009-9140-3465)
- Tomas Escobar‐Gil
Institutions
- University of New Mexico (US)
- University of Florida (US)
- New Mexico Cancer Center (US)
- Icesi University (CO)
Publication Details
- Journal
- European Journal of Case Reports in Internal Medicine
- Published
- 2025-08-27
- DOI
- https://doi.org/10.12890/2025_005724
- Citations
- 2
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 3.76