Associaties tussen suïcidaliteit en hyperthyreoïdie, en de klinische implicaties

The association between suicidality and hyperthyroidism and it’s clinical implications Suicidality is a common and complex phenomenon. The suicidal process is the result of multifactorial biopsychosocial influences. This literature review is a response to a clinical experience that led us to ask whether hyperthyroidism plays a role in the etiopathogenesis of suicidality. We searched PubMed, CORE, Embase, Limo, Web of Science, and Cochrane for relevant articles published between the start of the database and March 21, 2024. We found 132 articles using this search method. The articles were screened for title, abstract and content. A total of 15 articles were included in this review. We included 3 cohort studies, 6 cases from 2 case series and 10 case reports. The 3 cohort studies used 3 different databases in which diagnoses and deaths were registered. They examined 3 non-comparable populations. In total, it concerns 78,539 subjects of which 2,480 minors. The available cohort studies show a possible association between hyperthyroidism and an increased risk of suicide in adults on the one hand and suicidal ideation, suicide attempts and self-harm behaviour in minors on the other. The described cases indicate that treating uncontrolled hyperthyroidism brings the acute psychiatric complaints to remission.