Inhibitory effects of the flavonoids extracted from Pollen Typhae on palmitic acid-induced NLRP3 inflammasome activation in macrophages involving AMPK-mediated lipid metabolism
The findings highlight the ability of PTF and its active component TYP to inhibit PA-induced NLRP3 inflammasome activation in macrophages involving AMPK-mediated lipid metabolism, implying the potential use of PT flavonoid compounds as anti-diabetic inflammation lead compounds.
Authors
- Wei Ren (ORCID: https://orcid.org/0000-0002-6537-6039)
- Lu Li (ORCID: https://orcid.org/0000-0001-9739-2669)
- Yushan Yang (ORCID: https://orcid.org/0000-0003-3136-626X)
- Hongsheng Lin (ORCID: https://orcid.org/0000-0002-6945-8875)
- Huiming Duan
- Chunling Wang (ORCID: https://orcid.org/0000-0002-4187-6098)
- Aihua Tang
- Wei Nong
- Xiaotao Feng
Institutions
- Guangxi University (CN)
- The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s12906-025-05024-4
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Guangxi University