Intercellular signaling reinforces single-cell level phenotypic transitions and facilitates robust re-equilibrium of heterogeneous cancer cell populations
Our work highlights the critical role of intercellular signaling in sustaining intratumoral heterogeneity, and our approach of computational analysis of scRNA-seq data can infer inter- and intra-cellular signaling networks in a holistic manner.
Authors
- Daniel Lopez (ORCID: https://orcid.org/0009-0009-5804-2493)
- Darren R. Tyson (ORCID: https://orcid.org/0000-0002-3272-4308)
- Tian Hong (ORCID: https://orcid.org/0000-0002-8212-7050)
Institutions
- The University of Texas at Dallas (US)
- Duke University (US)
- Knoxville College (US)
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s12964-025-02405-7
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Science Foundation
- National Institutes of Health
- Directorate for Biological Sciences