Mn(III)-porphyrins in battle against neurodegenerative and cancer diseases

Manganese(III)-porphyrins - Mn(III)P-exhibit remarkable redox activity, influencing oxidative and antioxidative processes in biological systems. In this study, we explore the dual roles of Mn(III)-2-TE-PyP⁵⁺ and Mn(III)-4-TE-PyP⁵⁺ in modulating hyaluronan degradation, a key factor in both neuroprotection and cancer therapy. While Mn(III)-2-TE-PyP⁵⁺ enhances oxidative degradation of high-molecular weight hyaluronan, facilitating immune recognition of cancer cells, its structural isomer Mn(III)-4-TE-PyP⁵⁺ acts as a potent antioxidant, safeguarding neuronal integrity against oxidative stress. Employing rotational viscometry, oximetry, electron paramagnetic resonance (EPR), and gas chromatography-mass spectrometry (GC-MS), we delineate the mechanisms underlying the redox transformations of Mn(III)P-derivatives and their impact on glycocalyx integrity. Our findings provide new insights into the selective therapeutic applications of Mn(III)P-derivatives, offering promising strategies for targeted cancer treatment and neurodegenerative disease prevention.