A Positive Feedback Loop Between <scp>SPP1</scp> <sup>+</sup> Macrophages and Tumor Cells Promotes Head and Neck Squamous Cell Carcinoma Progression

SPP1-CD44 upregulates stemness and migration abilities of tumor cells in HNSCC. SPP1-CD44 forms an interaction and a positive feedback loop in SPP1<sup>+</sup>macrophages and tumor cells in HNSCC.

Authors

Haiyan Guo (ORCID: https://orcid.org/0009-0001-7706-1077)
Chun Liu (ORCID: https://orcid.org/0000-0001-5376-9196)
Chuwen Li (ORCID: https://orcid.org/0000-0002-5932-8188)
Jianjun Zhang (ORCID: https://orcid.org/0000-0002-8329-2357)
Kun Wu (ORCID: https://orcid.org/0000-0002-4813-5671)

Institutions

Central South University (CN)
Shanghai Jiao Tong University (CN)
Shanghai Ninth People's Hospital (CN)
Second Xiangya Hospital of Central South University (CN)

Publication Details

Journal: Journal of Oral Pathology and Medicine
Published: 2025-08-28
DOI: https://doi.org/10.1111/jop.70049
Citations: 1
Primary Topic: Epigenetics and DNA Methylation
Type: article
Field-Weighted Citation Impact: 0.81

Funders

National Natural Science Foundation of China

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article

A Positive Feedback Loop Between SPP1 ⁺ Macrophages and Tumor Cells Promotes Head and Neck Squamous Cell Carcinoma Progression

Haiyan Guo, Chun Liu, Chuwen Li, Jianjun Zhang et al.

Aug 28, 2025

1 citations

Journal of Oral Pathology and Medicine

Epigenetics and DNA Methylation

0.81

article

A Positive Feedback Loop Between SPP1 ⁺ Macrophages and Tumor Cells Promotes Head and Neck Squamous Cell Carcinoma Progression

Haiyan Guo, Chun Liu, Chuwen Li, Jianjun Zhang, Kun Wu

August 28, 2025article en

1 citations

Abstract

SPP1-CD44 upregulates stemness and migration abilities of tumor cells in HNSCC. SPP1-CD44 forms an interaction and a positive feedback loop in SPP1<sup>+</sup>macrophages and tumor cells in HNSCC.

Journal of Oral Pathology and MedicineVol. 54(10)

Central South University (CN), Shanghai Jiao Tong University (CN), Shanghai Ninth People's Hospital (CN), Second Xiangya Hospital of Central South University (CN)

National Natural Science Foundation of China

Openalex Percentile: Top 24%

Epigenetics and DNA Methylation

0.81

DOI Source OpenAlex

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A Positive Feedback Loop Between <scp>SPP1</scp> <sup>+</sup> Macrophages and Tumor Cells Promotes Head and Neck Squamous Cell Carcinoma Progression — Haiyan Guo, Chun Liu, et al. · Journal of Oral Pathology and Medicine (2025) | TGRS Research Map | TGRS