Associations between 1400 metabolites and subtypes of endometriosis: a two-sample Mendelian randomisation study

Our study suggests potential causal relationships between metabolites and various endometriosis subtypes from an MR perspective. However, the limited number of associations that survived multiple-testing correction indicates that these findings are preliminary and require validation in larger cohorts. This exploratory analysis may contribute to advancing future research on metabolomics-based diagnosis, treatment, and prevention of endometriosis.

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Publication Details

Journal
Journal of Obstetrics and Gynaecology
Published
2025-08-28
DOI
https://doi.org/10.1080/01443615.2025.2552402
Primary Topic
Endometriosis Research and Treatment
Type
article
Field-Weighted Citation Impact
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article

Associations between 1400 metabolites and subtypes of endometriosis: a two-sample Mendelian randomisation study

Zhijie Huang, Lingfeng Wu, Zhouxiang Chen, Fei Yan
1 links
Journal of Obstetrics and Gynaecology
Endometriosis Research and Treatment
article

Associations between 1400 metabolites and subtypes of endometriosis: a two-sample Mendelian randomisation study

Zhijie Huang, Lingfeng Wu, Zhouxiang Chen, Fei Yan
article en

Abstract

Our study suggests potential causal relationships between metabolites and various endometriosis subtypes from an MR perspective. However, the limited number of associations that survived multiple-testing correction indicates that these findings are preliminary and require validation in larger cohorts. This exploratory analysis may contribute to advancing future research on metabolomics-based diagnosis, treatment, and prevention of endometriosis.

Journal of Obstetrics and GynaecologyVol. 45(1)
Jiangxi University of Traditional Chinese Medicine (CN), Riverside Hospital of Guangxi Zhuang Autonomous Region (CN), Hezhou University (CN), First People's Hospital of Chongqing (CN)
Zero hunger
Openalex Percentile: Top 70%
Endometriosis Research and Treatment
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