Prognostic significance of tumor spread through air spaces and lymphovascular invasion in stage I non-small cell lung cancer: implications for adjuvant chemotherapy
STAS represents an independent adverse prognostic factor in stage I NSCLC, and conventional ACT appears to offer limited benefit in this group overall. Patients harboring both STAS and LVI may derive potential benefit from ACT, whereas STAS-negative patients may require careful evaluation to avoid overtreatment. These findings support the need for personalized, risk-adapted postoperative management strategies and warrant further prospective investigation.
Authors
- Tai-Huang Lee
- Jui‐Ying Lee (ORCID: https://orcid.org/0000-0002-0037-8631)
- Cheng‐Hao Chuang (ORCID: https://orcid.org/0000-0003-4239-4012)
- Inn‐Wen Chong (ORCID: https://orcid.org/0000-0001-8328-8684)
- Wei-An Lai (ORCID: https://orcid.org/0000-0002-3167-5399)
- Chia‐Yu Kuo (ORCID: https://orcid.org/0000-0003-4508-4394)
- M.-H. Lee
- Yu‐Wei Liu (ORCID: https://orcid.org/0000-0003-4803-6128)
- C. T. Wu
- Shih‐Yu Kao
- Jen‐Yu Hung (ORCID: https://orcid.org/0000-0002-0341-7747)
- Yi-Wen Shen (ORCID: https://orcid.org/0009-0005-8656-0395)
Institutions
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s12957-025-03980-2
- Citations
- 1
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Sun Yat-sen University
- Kaohsiung Medical University
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- National Science and Technology Council