From mitochondrial DNA arrangement to repair: a kinetoplast-associated protein with different roles in two trypanosomatid species
Proteins associated with DNA are evolutionarily conserved and usually perform similar functions in different organisms. Our findings reveal that KAP7 is involved in kDNA replication, but its roles differ in trypanosomatid species: in A. deanei, KAP7 is associated with kDNA arrangement, while in T. cruzi, it is related to mitochondrial metabolism, such as kDNA replication and damage response.
Authors
- María Cristina M. Motta (ORCID: https://orcid.org/0000-0002-0947-4830)
- Bruno Marçal Repolês (ORCID: https://orcid.org/0000-0001-5704-3093)
- Wanderley de Souza (ORCID: https://orcid.org/0000-0002-1895-1299)
- Jeremy C. Mottram (ORCID: https://orcid.org/0000-0001-5574-3766)
- Carlos Renato Machado (ORCID: https://orcid.org/0000-0002-8724-3165)
- Camila Silva Gonçalves (ORCID: https://orcid.org/0000-0003-3302-313X)
- Flávia Souza Morini
- Stênio Perdigão Fragoso (ORCID: https://orcid.org/0000-0002-0909-7940)
- Carolina Moura Costa Catta‐Preta (ORCID: https://orcid.org/0000-0001-8983-3487)
- Danielle Pereira Cavalcanti (ORCID: https://orcid.org/0000-0002-9689-6010)
- Wesley Roger Rodrigues Ferreira
Institutions
- Universidade Federal de Minas Gerais (BR)
- Universidade Federal do Rio de Janeiro (BR)
- Instituto Nacional de Metrologia, Qualidade e Tecnologia (BR)
- National Institute of Science and Technology for Structural Biology and Bioimaging (BR)
- University of York (GB)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s13071-025-06985-8
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais