Targeted soluble epoxide hydrolase inhibits M1 macrophage polarization to improve cartilage injury in temporomandibular joint osteoarthritis
Our study elucidates a novel role of TPPU in inhibiting M1 macrophage polarization and modulating inflammatory immune responses via the EETs/NF-κB/IL-17 axis, thereby inhibiting cartilage damage in TMJOA.
Authors
- Bing Yan (ORCID: https://orcid.org/0000-0001-5430-4761)
- Sha Liu (ORCID: https://orcid.org/0000-0002-6710-8126)
- Yi Li (ORCID: https://orcid.org/0000-0002-1519-0113)
- Yu Zhang (ORCID: https://orcid.org/0000-0003-3474-422X)
- Fu Wang (ORCID: https://orcid.org/0000-0001-9615-1038)
- Lu Gao (ORCID: https://orcid.org/0000-0002-9264-6655)
- Yiding Liu (ORCID: https://orcid.org/0000-0003-0540-9289)
Institutions
- Dalian Medical University (CN)
- Jinan Stomatological Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s12967-025-07003-2
- Citations
- 3
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- National Natural Science Foundation of China