Pediatric Generalized Pustular Psoriasis Responsive to Colchicine: A Cost‐Effective Alternative to Biologics
Generalized pustular psoriasis is uncommon in children and therapy is typically with systemic agents. While many drugs like oral retinoids, cyclosporine, methotrexate, and spesolimab are used, colchicine is a safe and underutilized drug that acts by inhibition of neutrophils and the TNF-α-NF-kβ pathway. We report a case of a 10-year-old with generalized pustular psoriasis refractory to cyclosporine and methotrexate who achieved complete remission within 6 weeks of colchicine monotherapy.
Authors
- Savitha Sharath (ORCID: https://orcid.org/0000-0001-7012-8964)
- Purnima Paliwal (ORCID: https://orcid.org/0000-0002-1517-7357)
- Kabir Sardana (ORCID: https://orcid.org/0000-0003-1757-3406)
- Arunesh Padmini Kathirvelu
- Aakanksha Marmat
Institutions
- Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital (IN)
Publication Details
- Journal
- Pediatric Dermatology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1111/pde.16024
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00