Postmortem Analysis 35 Months after Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor
This paper presents the first long-term (35-month) postmortem analysis of MRgFUS thalamotomy demonstrating sustained clinical efficacy. Postmortem MRI confirmed that the lesion remained localized to the original thalamotomy site, with focal disruption of the dentatorubrothalamic tract. Neuropathological examination revealed selective demyelination in the posterior thalamus near the treatment site, without evidence of neuronal loss. These findings support the long-term safety, precision, and durability of MRgFUS as a non-invasive therapeutic option for essential tremor.
Authors
- Josué M. Avecillas-Chasín (ORCID: https://orcid.org/0000-0001-5627-9643)
- Lorraina Robinson (ORCID: https://orcid.org/0009-0005-1098-4909)
- Qinwen Mao (ORCID: https://orcid.org/0000-0001-7876-2046)
- Lubdha M. Shah (ORCID: https://orcid.org/0000-0003-1303-3533)
- Viola Rieke
- Henrik Odéen (ORCID: https://orcid.org/0000-0003-2055-9795)
- Shervin Rahimpour (ORCID: https://orcid.org/0000-0003-2718-181X)
- Saachi Jhandi (ORCID: https://orcid.org/0000-0001-6740-0883)
- Heather Wisner
Institutions
- University of Nebraska–Lincoln (US)
- University of Utah (US)
- Spencer Foundation (US)
Publication Details
- Journal
- Tremor and Other Hyperkinetic Movements
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5334/tohm.1013
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00