Analysis of antimicrobial activity and biofilm inhibition of Ag-NHC complexes by in-vitro and molecular docking method
<b>1d</b> showed superior activity while <b>2a</b> and <b>2d</b> were effective against <i>C. albicans</i>, with activity comparable to fluconazole in the range of 8.6-8.7 µM. The highest binding affinity was recorded for 2a as -7.93 kcal/mol against DNA Gyrase, while <b>2b</b> has the best interactions with -5.49 kcal/mol against SarA. and -7.74 kcal/mol binding affinity was determined for <b>2a</b> with molecular docking. All the molecules interacted with the same grove of DNA.
Authors
- Uğur Tutar (ORCID: https://orcid.org/0000-0002-8058-0994)
- Elvan Üstün (ORCID: https://orcid.org/0000-0002-0587-7261)
- Neslihan Şahin (ORCID: https://orcid.org/0000-0003-1498-4170)
- Cem Çeli̇k (ORCID: https://orcid.org/0000-0002-7141-5874)
Institutions
- Sivas Cumhuriyet Üniversitesi (TR)
- Malatya Turgut Özal Üniversitesi (TR)
- Ordu University (TR)
- Turgut Özal University (TR)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1080/17568919.2025.2552635
- Primary Topic
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00