Associations among melanocortin-4 receptor rs17782313 gene polymorphisms, 12-week aerobic exercise combined with low-fat diet and degree of reduction in blood lipids in adults with obesity
The CC+CT genotype group, particularly males on a low-fat diet, showed robust improvements in TG, LDL-C, and insulin resistance markers. However, HDL-C responses were inconsistent across subgroups. Notably, males with the CC+CT allele exhibited the most pronounced benefits in LDL-C reduction and HOMA-IR improvement with a low-fat diet.
Authors
- Fei Wang (ORCID: https://orcid.org/0000-0001-9776-4792)
- Weimin Wang (ORCID: https://orcid.org/0000-0003-0995-8306)
- Xiaoyan Hao (ORCID: https://orcid.org/0000-0003-3841-1342)
- Qiang Zeng (ORCID: https://orcid.org/0000-0002-4961-0171)
- Dong Bai
- Shanshan Liu (ORCID: https://orcid.org/0009-0003-2276-428X)
- Liyuan Zheng
Institutions
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Digital China Health (China) (CN)
- eHealth Africa (US)
- Peking University Third Hospital (CN)
- Beijing Sport University (CN)
Publication Details
- Journal
- Postgraduate Medicine
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1080/00325481.2025.2552640
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China