Traumatic liver injury increases susceptibility to bacterial pneumonia in swine
We have developed a novel, clinically relevant, reproducible porcine model of abdominal injury with subsequent A. pleuropneumoniae pneumonia for the study and development of therapeutics against immune dysregulation induced by trauma. Additionally, a novel finding is that plasma from traumatized pigs provides a permissive environment for bacterial growth.
Authors
- Vanessa Azevedo Voltarelli (ORCID: https://orcid.org/0000-0003-0087-646X)
- Hyo In Kim (ORCID: https://orcid.org/0000-0002-3916-6855)
- Alexandra Scheiflinger
- Anupamaa Seshadri (ORCID: https://orcid.org/0000-0001-8432-7518)
- James E. Kirby (ORCID: https://orcid.org/0000-0003-0392-4500)
- Leo E. Otterbein (ORCID: https://orcid.org/0000-0002-7900-0825)
- James Harbison
- Eva Csizmadia (ORCID: https://orcid.org/0000-0003-1996-0370)
- Carl J. Hauser (ORCID: https://orcid.org/0000-0003-3167-1846)
- Jinbong Park (ORCID: https://orcid.org/0000-0002-5984-5855)
- David Gallo
Institutions
- Beth Israel Deaconess Medical Center (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1097/ta.0000000000004768
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 0.00