Reduced heparan sulfate levels in cerebrospinal fluid reflect brain neuron correction in Sanfilippo B mice
A biomarker in spinal fluid reflects brain disease in a rare genetic disorder, with implications for how we diagnose and monitor the disease.
Authors
- Patricia Dickson (ORCID: https://orcid.org/0000-0003-3467-8488)
- Grant L. Austin (ORCID: https://orcid.org/0000-0002-9122-1022)
- Alexander Sorensen
- Balraj Doray (ORCID: https://orcid.org/0000-0003-3347-5013)
- Jonathan D. Cooper (ORCID: https://orcid.org/0000-0003-1339-4750)
- Steven Q. Le
- Soila Sukupolvi
- Gianna Jewhurst
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Journal of Clinical Investigation
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1172/jci195268
- Citations
- 1
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Hope Center for Neurological Disorders
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurological Disorders and Stroke