The Causal Role of Gut Microbiota and Immune Cell Mediation in Gastroenteropancreatic Neuroendocrine Neoplasms: A Mendelian Randomization Study
Our MR analysis provides robust causal evidence that specific GM taxa significantly influence the risk of GEP-NENs, and that this effect is partially mediated through discrete subsets of circulating immune cells. These findings underscore the GM-immune axis as a novel preventive and therapeutic target in GEP-NENs.
Authors
- Zhichen Jiang (ORCID: https://orcid.org/0000-0002-7489-580X)
- Yuanyu Wang (ORCID: https://orcid.org/0000-0001-8462-7211)
- Fangxia Wang (ORCID: https://orcid.org/0000-0003-1737-4204)
- Huiqing Lu (ORCID: https://orcid.org/0000-0002-6636-0338)
- Jingtao Chen (ORCID: https://orcid.org/0000-0002-4720-4225)
- Chao Lü (ORCID: https://orcid.org/0000-0002-0762-5797)
- Mingyang Liu (ORCID: https://orcid.org/0000-0002-7427-2709)
- Pengcheng Ma (ORCID: https://orcid.org/0000-0002-1067-8021)
- Qicong Zhu
- Weiwei Jin (ORCID: https://orcid.org/0000-0002-2974-9598)
- Yiping Mou
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Hangzhou Medical College (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Neuroendocrinology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1159/000547998
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00