Effective Management of Carbapenem-Resistant Enterobacterales Bloodstream Infection with Organ Dissemination in Prolonged Severe Agranulocytosis Patients with Hematological Malignancy Through Combination Therapies Including Eravacycline
This study reports three patients with hematologic malignancy patients and Carbapenem-resistant Enterobacterales (CRE) bloodstream infections and organ dissemination during neutropenia. After failed conventional therapy, a novel "through Combination therapies including eravacycline" regimen achieved fever control within 10 days and lesion resolution by 20 days approximately, demonstrating breakthrough efficacy for CRE bacteremia management.
Authors
- X P Li
- Xiaowen Tang (ORCID: https://orcid.org/0000-0003-1766-7891)
- Qingya Cui (ORCID: https://orcid.org/0000-0002-5067-5650)
- Lian Bai (ORCID: https://orcid.org/0009-0001-6097-6828)
- Xiangwu Zhang (ORCID: https://orcid.org/0000-0002-6236-6281)
- Yue Lv (ORCID: https://orcid.org/0000-0001-8043-9651)
- Yan Yu (ORCID: https://orcid.org/0000-0003-0149-8165)
- Xiaoqian Chen (ORCID: https://orcid.org/0000-0001-9255-3371)
- Mengyun Li (ORCID: https://orcid.org/0009-0008-3488-7240)
- Depei Wu (ORCID: https://orcid.org/0009-0003-3176-9963)
Institutions
- Soochow University (CN)
- Cangzhou Central Hospital (CN)
- People's Hospital of Cangzhou (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Infectious Diseases and Therapy
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1007/s40121-025-01206-2
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bethune Charitable Foundation
- National Natural Science Foundation of China
- Soochow University