Micro- and nanoplastics are elevated in femoral atherosclerotic plaques compared with undiseased arteries
This work demonstrates high levels of micronanoplastics (MNPs) in human femoral artery atherosclerotic plaques as compared with healthy, nondiseased human carotid arteries. No clear associations between age and MNP levels were demonstrated amongst limb ischemia or control patients. Some individual polymers are associated with advanced atherosclerotic disease (chronic limb-threatening ischemia) compared with claudication. These data add to the growing literature suggesting that MNP particles accumulate in atherosclerotic lesions. Future work should investigate what mechanistic role, if any, MNPs may play in the pathophysiology of vascular atherosclerotic disease.
Authors
- Rowza T. Rumma
- Matthew J. Campen (ORCID: https://orcid.org/0000-0002-2292-5050)
- D. K. Kulkarni (ORCID: https://orcid.org/0000-0001-7372-5000)
- Carolyn Pace
- Ross Clark (ORCID: https://orcid.org/0000-0003-3712-8414)
- Matthew Justus
- Christopher Schlosser
- Pierce Massie (ORCID: https://orcid.org/0000-0003-3643-3791)
- Rui Liu (ORCID: https://orcid.org/0000-0003-2974-003X)
- Ann M. Decker (ORCID: https://orcid.org/0000-0001-7508-2096)
- Daniel Gallego (ORCID: https://orcid.org/0000-0002-7596-3974)
- Milad MazloumiBakhshayesh
- Marcus A. Garcia (ORCID: https://orcid.org/0000-0003-1198-8440)
Institutions
- University of New Mexico (US)
Publication Details
- Journal
- JVS Vascular Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jvssci.2025.100393
- Citations
- 4
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Pharmaceutical Research and Manufacturers of America Foundation
- National Institutes of Health
- National Institute of General Medical Sciences
- National Center for Advancing Translational Sciences