Prevalence of Incidental Breast Cancer and Precursor Lesions in Carriers of Pathogenic Germline Variants Undergoing Risk-Reducing Mastectomy
The study highlights the critical need for rigorous surveillance programs and advanced imaging protocols, particularly tailored to younger women at elevated risk of breast cancer, to ensure early detection of occult lesions. The implementation of interdisciplinary counseling and precise timing of risk-reducing mastectomy is essential to reduce the progression to preinvasive and invasive disease.
Authors
- JL Wagner (ORCID: https://orcid.org/0009-0001-2032-9562)
- Jens‐Uwe Blohmer (ORCID: https://orcid.org/0000-0002-7969-250X)
- Dorothee Speiser (ORCID: https://orcid.org/0000-0002-6447-629X)
- Catarina Alisa Kunze (ORCID: https://orcid.org/0000-0002-1150-0364)
- Ulrich Bick (ORCID: https://orcid.org/0000-0002-7254-8572)
- FLORENCE LEINHOS
Institutions
- Humboldt-Universität zu Berlin (DE)
- Wiener Krankenanstaltenverbund (AT)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-08-28
- DOI
- https://doi.org/10.21873/anticanres.17735
- Citations
- 1
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.82