5-HMF plays an intervention role in ischemic stroke by regulating GluR2 to improve mitochondrial function and promote angiogenesis
5-HMF has the effect of ameliorating brain damage in MCAO rats, and by regulating the expression of GluR2, reducing intracellular Ca<sup>2+</sup> concentration, improving mitochondrial function, promoting angiogenesis, thereby reducing OGD-R-induced HBMECs damage.
Authors
- Peipei Yuan (ORCID: https://orcid.org/0000-0003-0807-0196)
- Xiaoke Zheng (ORCID: https://orcid.org/0000-0003-3671-231X)
- Yan Zhang (ORCID: https://orcid.org/0000-0001-5738-9537)
- Yan Huo (ORCID: https://orcid.org/0000-0002-9379-6364)
- Yaxin Wei (ORCID: https://orcid.org/0000-0001-8366-6286)
- Qing‐Yun Ma
- Saifei Li (ORCID: https://orcid.org/0000-0002-4123-2567)
- Weisheng Feng
- Lirui Zhao (ORCID: https://orcid.org/0009-0002-3519-6456)
Institutions
- Ministry of Education (IR)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102208
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00