Altered lateral geniculate nucleus functional connectivity and its correlation with retinal thickness in primary open-angle glaucoma: A resting-state functional MRI study
Patients with POAG exhibited LGN atrophy, reduced resting-state functional activity, and altered FC with the LGN in the regional cortex. The glaucomatous impairment of retinal thickness was associated with LGN volume and its connectivity strength with the left MFG. These findings offer a deeper insight into the LGN cortical connectivity alterations and its association with transneuronal degeneration in patients with POAG.
Authors
- Xinyue Shen
- Yehong Zhuo (ORCID: https://orcid.org/0000-0003-3247-7199)
- Shaofen Huang
- Ning Wu (ORCID: https://orcid.org/0000-0001-7485-0436)
- Caibin Deng (ORCID: https://orcid.org/0000-0001-7663-661X)
- Yangjiani Li (ORCID: https://orcid.org/0000-0003-4327-4602)
- Zhidong Li (ORCID: https://orcid.org/0000-0002-2211-6843)
- Xuhao Chen (ORCID: https://orcid.org/0000-0003-1334-223X)
- Yiqing Li (ORCID: https://orcid.org/0000-0001-7021-0992)
- Ye Deng
- Yue Xiao
- Yingting Zhu (ORCID: https://orcid.org/0000-0002-9682-1748)
- Lingjing Hu
Institutions
- Sun Yat-sen University (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111524
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Capital Medical University
- China Postdoctoral Science Foundation
- Beijing Municipal Education Commission
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province