Thorough Lymphadenectomy Impairs Immunotherapy Outcomes for Postoperative Intrathoracic Recurrence of Non-small Cell Lung Cancer
Extensive lymphadenectomy may worsen the prognostic outcomes of ICI monotherapy, possibly by impairing tumor-draining lymph node-mediated immunity. These findings highlight the importance of lymphatic preservation and support the clinical rationale for neoadjuvant ICI therapy for resectable NSCLC.
Authors
- Koki Maeda (ORCID: https://orcid.org/0000-0001-9083-2588)
- Aya Takeda (ORCID: https://orcid.org/0000-0002-7982-8104)
- Kazuhiro Ueda (ORCID: https://orcid.org/0000-0003-0030-0882)
- Toshiyuki Nagata (ORCID: https://orcid.org/0000-0003-1736-759X)
- Masaya Aoki (ORCID: https://orcid.org/0000-0003-1769-5382)
- Shoichiro Morizono
- Kota Kariatsumari
- Takuya Tokunaga (ORCID: https://orcid.org/0000-0002-0709-2214)
- Go Kamimura
- Yusei Tsuneyoshi
Institutions
- Kagoshima University (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-08-28
- DOI
- https://doi.org/10.21873/anticanres.17755
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00