TGF-B-induced Cancer-associated Fibroblast Activation Promotes Tumor Progression In Oral Squamous Cell Carcinoma Mouse Model
These findings suggest that TGF-β induces CAF differentiation and facilitates tumor progression by promoting angiogenesis and extracellular matrix degradation. This study highlights the potential of targeting TGF-β as a therapeutic strategy and underscores the need for novel approaches to counteract the tumor-promoting effects of CAFs.
Authors
- Yudai Matsuzoe
- Junya Hirota
- Masaya Akashi (ORCID: https://orcid.org/0000-0003-0432-3299)
- Yoshiaki Tadokoro (ORCID: https://orcid.org/0000-0002-8079-1484)
- Takumi Hasegawa (ORCID: https://orcid.org/0000-0002-7349-7084)
- Daisuke Takeda (ORCID: https://orcid.org/0009-0000-5878-8871)
- Izumi Saito (ORCID: https://orcid.org/0000-0002-7369-6729)
- Yujiro Sadakane
- Aki Murakami
- Nanae Yatagai
Institutions
- Kobe University (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-08-28
- DOI
- https://doi.org/10.21873/anticanres.17731
- Citations
- 2
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61