Role of interleukin-7 in acute large vessel occlusion stroke
Intracranial IL-7 is a significant predictor of infarct burden in ELVO stroke, highlighting its role in localized immune responses. Systemic IL-7 lacked predictive value, suggesting spatially restricted IL-7 signaling within the ischemic environment. IL-7 may serve as a biomarker for stroke severity and a potential therapeutic target.
Authors
- Keith R. Pennypacker (ORCID: https://orcid.org/0000-0002-4618-0903)
- Justin F. Fraser (ORCID: https://orcid.org/0000-0002-5980-3989)
- Ann Stowe (ORCID: https://orcid.org/0000-0001-8111-4429)
- Amanda L. Trout (ORCID: https://orcid.org/0000-0002-4754-8634)
- Jason Zhao
- Mais Al‐Kawaz (ORCID: https://orcid.org/0000-0002-0978-8012)
- David Dornbos (ORCID: https://orcid.org/0000-0002-0039-0016)
- Jacqueline A. Frank (ORCID: https://orcid.org/0000-0002-3216-518X)
- Shivani Pahwa (ORCID: https://orcid.org/0009-0004-7352-5913)
Institutions
- University of Notre Dame (US)
- University of Kentucky (US)
Publication Details
- Journal
- Journal of NeuroInterventional Surgery
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1136/jnis-2025-023637
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Academy of Medical Sciences