MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model
Our findings reveal that Ms4a6d deficiency suppresses neuroprotection and worsens neuroinflammation. Sufficient Ms4a6d maybe beneficial for boosting amyloid-related responses and suppressing inflammation in microglia, making it superior than previously reported candidates for microglia modulation. Thus, the elevated MS4A6A levels in AD are likely compensatory and boosting MS4A6A could be an effective treatment.
Authors
- Jin‐Tai Yu (ORCID: https://orcid.org/0000-0002-7686-0547)
- Chenyun Wu (ORCID: https://orcid.org/0000-0002-7468-9360)
- Shanshan Han (ORCID: https://orcid.org/0000-0002-7382-6028)
- Peng Yuan (ORCID: https://orcid.org/0000-0003-4051-4447)
- Piaopiao Lian
- Tian‐Lin Cheng (ORCID: https://orcid.org/0000-0003-0680-6710)
- Yi‐Jun Ge
- Bang‐Sheng Wu (ORCID: https://orcid.org/0000-0002-8807-6354)
- Lin Huang (ORCID: https://orcid.org/0009-0005-2419-0771)
- Kaimin Wu (ORCID: https://orcid.org/0000-0002-3307-6306)
- Yiting Li (ORCID: https://orcid.org/0000-0003-2164-7068)
- Yizhe Hao (ORCID: https://orcid.org/0000-0001-7659-2469)
- Ying Liu (ORCID: https://orcid.org/0000-0002-7260-6218)
- Haishan Jiao
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1186/s13024-025-00887-0
- Citations
- 4
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Fudan University