Cardiovascular-kidney-metabolic syndrome stage predicts cardiovascular outcomes in cancer patients: a real-world data analysis of a nationwide epidemiological dataset
The CKM staging system effectively stratifies cardiovascular risk in cancer patients, with higher stages predicting significantly worse outcomes. These findings advocate for integrating CKM assessment into onco-cardiologic practice to guide early intervention and improve patient outcomes.
Authors
- Norihiko Takeda (ORCID: https://orcid.org/0000-0003-1023-6116)
- Yuta Suzuki (ORCID: https://orcid.org/0000-0002-9406-4691)
- Hidehiro Kaneko (ORCID: https://orcid.org/0000-0003-2553-6170)
- Hiroyuki Morita
- Norifumi Takeda (ORCID: https://orcid.org/0000-0003-4818-3347)
- Katsuhito Fujiu
- Masaomi Nangaku (ORCID: https://orcid.org/0000-0001-7401-2934)
- Kaori Hayashi (ORCID: https://orcid.org/0000-0002-4923-1550)
- Takahiro Jimba (ORCID: https://orcid.org/0000-0002-3757-3959)
- Koichi Node (ORCID: https://orcid.org/0000-0002-2534-0939)
- Akira Okada (ORCID: https://orcid.org/0000-0001-5740-4346)
- Kentaro Ejiri (ORCID: https://orcid.org/0000-0001-6645-2075)
- Hideo Yasunaga (ORCID: https://orcid.org/0000-0002-6017-469X)
- Tatsuhiko Azegami (ORCID: https://orcid.org/0000-0002-4809-5788)
- Toshiyuki Ko (ORCID: https://orcid.org/0000-0002-9043-064X)
- Atsushi Mizuno
Institutions
- Okayama University (JP)
- Saga University (JP)
- Keio University (JP)
- St. Luke's International Hospital (JP)
- National Institute of Public Health (JP)
- Keio University Hospital (JP)
- University of Tokyo Health Sciences (JP)
- Department of Health (IE)
- The University of Tokyo (JP)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1093/ehjopen/oeaf115
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Foundation for Applied Enzymology
- Uehara Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Daiichi Sankyo Foundation of Life Science
- SENSHIN Medical Research Foundation
- Japan Heart Foundation
- Japan Society for the Promotion of Science
- Daiichi Sankyo Europe