Use of MRI-double inversion recovery sequence for early diagnosis of multiple sclerosis: case series

The choice of additional Double Inversion Recovery (DIR) Magnetic Resonance Imaging (MRI) sequences may affect the judgment of the presence and nature of lesions. Herein, we reported three cases initially presenting with non-typical multiple sclerosis (MS) symptoms, in which the final diagnosis of MS was confirmed after incorporating spinal cord and brain DIR MRI sequence. The sequence revealed more conspicuous lesions compared to conventional T2-weighted imaging or T2-weighted fluid-attenuated inversion recovery (T2WI/FLAIR) sequences. Consequently, the patients received an earlier definitive diagnosis and timely treatment. Our cases demonstrated the additional DIR sequences for the patients with non-typical MS symptoms were reasonable and may be helpful.