Antimicrobial GH12-fibrin hydrogel for dental pulp regeneration: An in vitro study

These results suggest that GH12-fibrin hydrogels might control endodontic infection, as it shows significant antibacterial activity without compromising the hydrogel's structure or cytocompatibility with DP-MSCs. Further studies in vitro and in vivo, are required to optimise GH12 release from the fibrin hydrogel and confirm its safety and effectiveness.

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Publication Details

Journal
Dental Materials
Published
2025-08-28
DOI
https://doi.org/10.1016/j.dental.2025.08.010
Citations
1
Primary Topic
Endodontics and Root Canal Treatments
Type
article
Field-Weighted Citation Impact
1.79

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article

Antimicrobial GH12-fibrin hydrogel for dental pulp regeneration: An in vitro study

Mourad Bekhouche, Raphaël Richert, Cédric Orelle, Jérôme Sohier et al.
1 citations
Dental Materials
Endodontics and Root Canal Treatments
1.79
article

Antimicrobial GH12-fibrin hydrogel for dental pulp regeneration: An in vitro study

Mourad Bekhouche, Raphaël Richert, Cédric Orelle, Jérôme Sohier, M. Lévêque, Maxime Ducret, Éric Diesis, Jean‐Daniel Malcor, Jean‐Christophe Farges, Edwin-Joffrey Courtial, Marjorie Faure, Lisa Reiniche
article en
1 citations

Abstract

These results suggest that GH12-fibrin hydrogels might control endodontic infection, as it shows significant antibacterial activity without compromising the hydrogel's structure or cytocompatibility with DP-MSCs. Further studies in vitro and in vivo, are required to optimise GH12 release from the fibrin hydrogel and confirm its safety and effectiveness.

Dental MaterialsVol. 41(12)
Université Claude Bernard Lyon 1 (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Université de Lyon (FR), Structural and Molecular Basis of Infectious Systems (FR), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (FR), Hospices Civils de Lyon (FR), Laboratoire de Biologie et Modélisation de la Cellule (FR), Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique (FR), Laboratoire de Mécanique des Contacts et des Structures (FR), Institut National des Sciences Appliquées de Lyon (FR)
Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
Openalex Percentile: Top 13%
Endodontics and Root Canal Treatments
1.79
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