The pivotal role of <i>acnA</i> in linking carbon metabolism to virulence and antimicrobial resistance in methicillin-resistant <i>Staphylococcus aureus</i>
These findings establish acnA as a metabolic nexus coordinating virulence and antimicrobial resistance in MRSA, highlighting its potential as a therapeutic target to disarm persistent infections through metabolic interference.
Authors
- Wanwan Hou (ORCID: https://orcid.org/0000-0002-9813-4554)
- Jiang Chang (ORCID: https://orcid.org/0000-0002-9145-7713)
- Chunlei Shi (ORCID: https://orcid.org/0000-0002-5847-7122)
- Xiaorong Tian
- Zengfeng Zhang (ORCID: https://orcid.org/0000-0002-7062-7613)
- Mu He
- Jiahui Li
Institutions
- Shanghai Jiao Tong University (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-08-13
- DOI
- https://doi.org/10.1093/jac/dkaf317
- Citations
- 1
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China