Targeting TGFβ docking receptor glycoprotein A repetitions predominant (GARP) via novel chimeric antigen receptor (CAR)-T cell platform to treat glioblastoma
GARP-LTGFβ plays a key role in the development and prognostics of GBM, and GARP-targeted CAR-T therapy shows promising efficacy and safety in murine orthotopic GBM models. A first-in-human phase I clinical trial for patients with recurrent GBM began to enroll patients in May 2025 (NCT06964737).
Authors
- Zihai Li (ORCID: https://orcid.org/0000-0003-4603-927X)
- José Javier Otero (ORCID: https://orcid.org/0000-0003-0680-4520)
- Pierre Giglio (ORCID: https://orcid.org/0000-0001-5165-0984)
- Qin Ma (ORCID: https://orcid.org/0000-0002-3264-8392)
- Daniel Kreatsoulas (ORCID: https://orcid.org/0000-0002-9727-7019)
- Jay K. Mandula (ORCID: https://orcid.org/0000-0003-2542-8073)
- Chelsea Bolyard
- Damien Gerald
- Hakan Çam (ORCID: https://orcid.org/0000-0002-5057-9757)
- Payton Weltge (ORCID: https://orcid.org/0000-0001-9404-6744)
- Maria Velegraki (ORCID: https://orcid.org/0000-0003-3062-9777)
- Bill X. Wu (ORCID: https://orcid.org/0000-0001-5759-0935)
- Prajwal Rajappa (ORCID: https://orcid.org/0000-0002-5911-9554)
- Dongjun Chung (ORCID: https://orcid.org/0000-0002-8072-5671)
- Yuzhou Chang (ORCID: https://orcid.org/0000-0003-4893-1886)
- P.W. Welsh
- J. Bradley Elder (ORCID: https://orcid.org/0000-0002-6650-3271)
- Anqi Li (ORCID: https://orcid.org/0000-0002-3037-9483)
- Ziyu Wang (ORCID: https://orcid.org/0000-0002-8212-3260)
Institutions
- Nationwide Children's Hospital (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- The Ohio State University Wexner Medical Center (US)
- Neurological Surgery (US)
- The Ohio State University (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-08-20
- DOI
- https://doi.org/10.1093/neuonc/noaf195
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Pelotonia
- National Institutes of Health