HADHB mediates 5-fluorouracil sensitivity in colorectal cancer
HADHB overexpression is linked to 5FU resistance in CRC, indicating it as a potential therapeutic target, likely via the HADHB-DUOX2-ROS pathway.
Authors
- Dan Li (ORCID: https://orcid.org/0000-0002-4852-5485)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-3856-5053)
- Jing Han (ORCID: https://orcid.org/0000-0003-1754-6782)
- Hui Jin (ORCID: https://orcid.org/0000-0003-0297-3052)
- Jiayin Liu (ORCID: https://orcid.org/0000-0001-7554-9661)
Institutions
- Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1007/s12672-025-03503-1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hebei Province