Exploratory study of peripheral immune changes associated with diffusion <scp>MRI</scp> multi‐compartment model in temporal lobe epilepsy
Group differences indicate a significant relationship between NODDI biomarkers of injury/neuroinflammation and peripheral immune cells and pro-inflammatory biomarkers in aTL. These novel in vivo findings support further the development of NODDI as a promising non-invasive technique for visualizing neuroinflammation. Further validation of NODDI may enable clinicians to use this approach for monitoring disease progression and treatment response in epilepsy, potentially leading to more personalized treatment strategies.
Authors
- Christina Mueller (ORCID: https://orcid.org/0000-0002-6127-6700)
- Rodolphe E. Nenert (ORCID: https://orcid.org/0000-0002-1743-3764)
- Jerzy P. Szaflarski (ORCID: https://orcid.org/0000-0002-5936-6627)
- Etty Benveniste (ORCID: https://orcid.org/0000-0003-4120-5750)
- Ayushe A. Sharma (ORCID: https://orcid.org/0000-0001-8194-2232)
- Huixian Hong (ORCID: https://orcid.org/0000-0001-7283-8775)
- Hongwei Qin (ORCID: https://orcid.org/0000-0002-5453-8661)
Institutions
- University of Alabama at Birmingham (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1111/epi.18612
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Center for AIDS Research, University of Washington
- National Institute of Neurological Disorders and Stroke