Stratifying Skin Cancer Patients and Guiding Treatment Decisions Through Combined p53 and p63 Expression Analysis
Distinct expression patterns of p53 and p63 suggest stage-specific roles in skin carcinogenesis. Elevated p53 in early lesions supports its tumor-suppressive function, while p63 may contribute to tumor maintenance in advanced stages. These findings support the utility of p53 and p63 as biomarkers for diagnosis and prognosis in skin cancer, and potential targets for future therapies.
Authors
- A Bini
- Andreas C. Lazaris (ORCID: https://orcid.org/0000-0002-8118-7780)
- S. Stavrianos (ORCID: https://orcid.org/0000-0002-9635-7869)
- Alexander Schramm (ORCID: https://orcid.org/0000-0001-7670-7529)
- Andreas Sakkas (ORCID: https://orcid.org/0000-0002-1268-6375)
- Maria Kouri (ORCID: https://orcid.org/0000-0002-0009-4911)
- Georgia Vairaktari
- Antonis Vylliotis
- Spyridoula Derka (ORCID: https://orcid.org/0009-0001-5163-878X)
- Marcel Ebeling (ORCID: https://orcid.org/0000-0003-3417-2786)
- Veronica Papakosta (ORCID: https://orcid.org/0000-0003-4033-1181)
- Efstathia Vairaktari (ORCID: https://orcid.org/0009-0007-4705-7660)
Institutions
- Universität Ulm (DE)
- National and Kapodistrian University of Athens (GR)
- University General Hospital Attikon (GR)
- University Hospital Ulm (DE)
Publication Details
- Journal
- In Vivo
- Published
- 2025-08-28
- DOI
- https://doi.org/10.21873/invivo.14060
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00