Cantharidin Suppresses Cell Viability and Induces Apoptosis of SK-N-SH and SH-SY5Y Cells
These findings support the hypothesis that cantharidin induces apoptosis <i>via</i> both intrinsic and extrinsic pathways, as well as through suppression of the JAK2-STAT3 axis. Our results reveal that cantharidin holds significant promise as a multi-target therapeutic candidate for NBL, justifying additional <i>in vivo</i> validation and clinical translation efforts.
Authors
- Chia-Wen Tsai (ORCID: https://orcid.org/0000-0002-8324-6596)
- JEN-SHENG PEI (ORCID: https://orcid.org/0000-0003-1775-4397)
- Te‐Chun Hsia (ORCID: https://orcid.org/0000-0003-4297-9918)
- Hsu‐Tung Lee (ORCID: https://orcid.org/0000-0002-0992-2568)
- Pei‐Chen Hsu
- Jaw-Chyun Chen
- WEN-SHIN CHANG (ORCID: https://orcid.org/0000-0003-1735-2857)
- DA-TIAN BAU
- CHAO-CHUN CHEN
Institutions
- National Chung Hsing University (TW)
- China Medical University (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- In Vivo
- Published
- 2025-08-28
- DOI
- https://doi.org/10.21873/invivo.14064
- Primary Topic
- Beetle Biology and Toxicology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taichung Veterans General Hospital
- Tao Yuan General Hospital, Ministry of Health and Welfare