Proinflammatory Effect of Mesenchymal Stem Cells From Patients With Multiple Sclerosis
Our results suggest that blocking ADAM-28 and OPN interaction with cognate receptors or increasing IL-10 reduces the proinflammatory potential of MSCs from people with MS. Similar approaches could be used in clinical MSC treatments.
Authors
- Louise C. Showe (ORCID: https://orcid.org/0000-0002-7818-4220)
- P.D.S.U. Wickramasinghe
- Nanci Frakich
- Andrew V. Kossenkov (ORCID: https://orcid.org/0000-0002-1536-0418)
- Bruno Gran (ORCID: https://orcid.org/0000-0001-6384-2342)
- Sergio L. Colombo (ORCID: https://orcid.org/0000-0001-7360-986X)
- Sarah Thevathas
- Rhodri E. Jones
- Kiranmai Gumireddy
- Cris S. Constantinescu (ORCID: https://orcid.org/0000-0003-2066-7585)
- David Onion (ORCID: https://orcid.org/0000-0002-4522-2307)
- Radu Tănăsescu (ORCID: https://orcid.org/0000-0003-2282-1793)
- Ian Spendlove (ORCID: https://orcid.org/0000-0002-7480-3768)
- Sonali Majumdar (ORCID: https://orcid.org/0000-0002-6574-8787)
- Cherry Chang
Institutions
- The Wistar Institute (US)
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Cooper Medical School of Rowan University (US)
- Institute of Mental Health (GB)
- Queen's Medical Centre (GB)
- Nottingham Trent University (GB)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1212/nxi.0000000000200444
- Citations
- 1
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 1.63