Total Synthesis of Dahurelmusin A and <i>epi</i>-Dahurelmusin A: Effect of a Single Stereocenter Change on Biological Activity
Reported herein is a total synthesis of the peptide-polyketide natural product dahurelmusin A along with its C10 epimer (<i>epi</i>-dahurelmusin A). The syntheses benefited from well-established aldol and macrocyclization technologies. Access to the natural product and its C10 epimer provided opportunities to test the importance of the C10 stereocenter in the biological activity of the natural product.
Authors
- Taku Okada (ORCID: https://orcid.org/0000-0002-0195-3335)
- Richmond Sarpong
- Blane P. Zavesky (ORCID: https://orcid.org/0009-0006-7795-3397)
- Pierre Thesmar (ORCID: https://orcid.org/0000-0003-1359-519X)
Institutions
- University of California System (US)
- Corteva (United States) (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1021/acs.orglett.5c03361
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Corteva Agriscience
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Astellas Foundation for Research on Metabolic Disorders
- National Institutes of Health