<i>meta</i>-Substituted Diaryliodonium Salts Enabled Aryne 1,2,4′-Trifunctionalization
A novel 1,2,4'-trifunctionalization of arynes was accomplished using <i>meta</i>-substituted diaryliodonium salts through a unique [5,5]-sigmatropic shift followed by a thia-Fries rearrangement. This cascade transformation enables the sequential formation of both C-N and C-S bonds, while also achieving the synthetically challenging <i>para</i>-selective C-C bond on the non-aryne aromatic ring.
Authors
- Li-Feng Chu
- Jianwei Han (ORCID: https://orcid.org/0000-0002-8354-5684)
- Junjie Jiang (ORCID: https://orcid.org/0000-0001-8322-3397)
- Limin Wang (ORCID: https://orcid.org/0000-0002-4025-5361)
Institutions
- East China University of Science and Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1021/acs.orglett.5c03311
- Citations
- 1
- Primary Topic
- Cyclization and Aryne Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China