Low Th2 and high PD1+ TFh cells in blood predict remission after CTLA-4Ig treatment for 48 weeks in early rheumatoid arthritis
Circulating Th2 and PD1+ TFh cell proportions at baseline may serve as predictive biomarkers for achieving CDAI remission after 48 weeks of CTLA-4Ig treatment in eRA.
Authors
- Tilia Selldén (ORCID: https://orcid.org/0009-0006-7969-4157)
- Kerstin Andersson (ORCID: https://orcid.org/0000-0001-6302-7006)
- Ronald van Vollenhoven (ORCID: https://orcid.org/0000-0001-6438-8663)
- Gerður Gröndal (ORCID: https://orcid.org/0009-0009-6751-3330)
- Kristina Lend (ORCID: https://orcid.org/0000-0001-5037-5546)
- Till Uhlig (ORCID: https://orcid.org/0000-0002-6881-9552)
- Anna‐Karin Hultgård Ekwall (ORCID: https://orcid.org/0000-0001-8236-6089)
- Tuulikki Sokka Isler
- Kim Hørslev‐Petersen (ORCID: https://orcid.org/0000-0002-5475-7610)
- Dan Nordström
- Cristina Maglio (ORCID: https://orcid.org/0000-0002-3786-5767)
- Björn Guðbjörnsson (ORCID: https://orcid.org/0000-0003-4631-6505)
- Merete Lund Hetland (ORCID: https://orcid.org/0000-0003-4229-6818)
- Michael Twahier Nurmohamed (ORCID: https://orcid.org/0000-0002-6274-1934)
- Jon Lampa (ORCID: https://orcid.org/0000-0002-7856-3968)
- Anna Rudin (ORCID: https://orcid.org/0000-0002-4137-1276)
- Anna‐Carin Lundell (ORCID: https://orcid.org/0000-0002-4303-8266)
- Marte Schrumpf Heiberg (ORCID: https://orcid.org/0000-0003-1104-7755)
- Inger Gjertsson (ORCID: https://orcid.org/0000-0002-9301-4844)
Institutions
- University of Copenhagen (DK)
- University of Helsinki (FI)
- University of Iceland (IS)
- University of Eastern Finland (FI)
- University of Southern Denmark (DK)
- Helsinki University Hospital (FI)
- Sahlgrenska University Hospital (SE)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- National University Hospital of Iceland (IS)
- Diakonhjemmet Hospital (NO)
- Central Finland Health Care District (FI)
- Sygehus Sønderjylland (DK)
- University of Gothenburg (SE)
- University of Amsterdam (NL)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1371/journal.pone.0330823
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Västra Götalandsregionen
- IngaBritt och Arne Lundbergs Forskningsstiftelse
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset